Collaborative work on evaluation of ovarian toxicity

Views inspired from a recent paper: Recommendation on the nonparametric Dunnett test using collaborative work on the evaluation of ovarian toxicity.

P-58: Evaluation of Ovarian Toxicity Effects of Chlorpromazine in Female Rats

Background: Elevations in serum prolactin levels (hyperprolactinaemia) are a common side effect of conventional antipsychotic treatments. The main objective of this study was to consider the effects of the antipsychotic drug chlorpromazine (CPZ) in female rats reproductive system and to examine the relationship between the effects on reproductive organs and hormone concentrations. Materials and...

O-17: Human Ovarian Tissue Xenotransplantation Application in Drug Discover

Background: Reproductive toxicity studies (RTS) represent an important part of pre-clinical safety evaluation of any drug development process for human consumption. It is mandatory requirement that RTS must be completed before any drug can be administered to women of childbearing age. Therefore, at first segment of toxicity check the toxic effect of the drug on fertility must be tested on non-c...

Collaborative work on evaluation of ovarian toxicity. 8) Two- or four-week repeated-dose studies and fertility study of Anastrozole in female rats.

The main focus of this study was to determine the optimal administration period in terms of toxic effects on ovarian morphological changes. To assess the morphological and functional changes induced by anastrozole in ovaries, the compound was administered to female rats at dose levels or 0, 0.01, 0.1 and 50 mg/kg for 2 or 4 weeks in the repeated dose toxicity study and at levels of 0, 0.01, 0.1...

Collaborative work on evaluation of ovarian toxicity. 17) Two- or four-week repeated-dose studies and fertility study of sulpiride in female rats.

To find the appropriate dosing period to detect ovarian toxicity, sulpiride, a D2 antagonist was orally dosed to female rats at dose levels of 1, 10, and 100 mg/kg/day daily for 2 or 4 weeks in repeated-dose toxicity studies. In addition, sulpiride at the same dose levels was given to female rats daily during the pre-mating period, mating period, and Days 0-7 of gestation to assess its effect o...